Uncoupled responses of Smad4-deficient cancer cells to TNFα result in secretion of monomeric laminin-γ2

BACKGROUND: Functional loss of the tumor suppressor Smad4 is involved in pancreatic and colorectal carcinogenesis and has been associated with the acquisition of invasiveness. We have previously demonstrated that the heterotrimeric basement membrane protein laminin-332 is a Smad4 target. Namely, Sma...

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Bibliografiske detaljer
Main Authors: Zboralski, Dirk, Warscheid, Bettina, Klein-Scory, Susanne, Malas, M Bassel, Becker, Heiko, Böckmann, Miriam, Meyer, Helmut E, Schmiegel, Wolff, Simon-Assmann, Patricia, Schwarte-Waldhoff, Irmgard
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853515/
https://ncbi.nlm.nih.gov/pubmed/20307265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-65
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