Divergent mechanisms underlie Smad4-mediated positive regulation of the three genes encoding the basement membrane component laminin-332 (laminin-5)

BACKGROUND: Functional inactivation of the tumor suppressor Smad4 in colorectal and pancreatic carcinogenesis occurs coincident with the transition to invasive growth. Breaking the basement membrane (BM) barrier, a prerequisite for invasive growth, can be due to tumor induced proteolytic tissue remo...

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Detalhes bibliográficos
Main Authors: Zboralski, Dirk, Böckmann, Miriam, Zapatka, Marc, Hoppe, Sabine, Schöneck, Anna, Hahn, Stephan A, Schmiegel, Wolff, Schwarte-Waldhoff, Irmgard
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525660/
https://ncbi.nlm.nih.gov/pubmed/18664273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-215
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