High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition

BACKGROUND: Smad4 is a tumour suppressor frequently inactivated in pancreatic and colorectal cancers. We have recently reported loss of Smad4 in every fourth carcinoma of the uterine cervix. Smad4 transmits signals from the TGF-β superfamily of cytokines and functions as a versatile transcriptional...

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Détails bibliographiques
Auteurs principaux: Klein-Scory, Susanne, Zapatka, Marc, Eilert-Micus, Christina, Hoppe, Sabine, Schwarz, Elisabeth, Schmiegel, Wolff, Hahn, Stephan A, Schwarte-Waldhoff, Irmgard
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2007
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2186346/
https://ncbi.nlm.nih.gov/pubmed/17997817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-7-209
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