Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis

Smad4/DPC4 (deleted in pancreatic carcinoma, locus 4) is a tumor suppressor gene lost at high frequency in cancers of the pancreas and other gastrointestinal organs. Smad4 encodes a key intracellular messenger in the transforming growth factor β (TGF-β) signaling cascade. TGF-β is a potent inhibitor...

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Detalhes bibliográficos
Main Authors: Schwarte-Waldhoff, Irmgard, Volpert, Olga V., Bouck, Noël P., Sipos, Bence, Hahn, Stephan A., Klein-Scory, Susanne, Lüttges, Jutta, Klöppel, Günter, Graeven, Ulrich, Eilert-Micus, Christina, Hintelmann, Annette, Schmiegel, Wolff
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC16915/
https://ncbi.nlm.nih.gov/pubmed/10944227
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