Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis

Smad4/DPC4 (deleted in pancreatic carcinoma, locus 4) is a tumor suppressor gene lost at high frequency in cancers of the pancreas and other gastrointestinal organs. Smad4 encodes a key intracellular messenger in the transforming growth factor β (TGF-β) signaling cascade. TGF-β is a potent inhibitor...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Schwarte-Waldhoff, Irmgard, Volpert, Olga V., Bouck, Noël P., Sipos, Bence, Hahn, Stephan A., Klein-Scory, Susanne, Lüttges, Jutta, Klöppel, Günter, Graeven, Ulrich, Eilert-Micus, Christina, Hintelmann, Annette, Schmiegel, Wolff
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 2000
Fag:	Biological Sciences
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16915/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10944227/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.17.9624
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