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PKC-α mediates flow-stimulated superoxide production in thick ascending limbs

We showed that luminal flow increases net superoxide (O(2)(−)) production via NADPH oxidase in thick ascending limbs. Protein kinase C (PKC) activates NADPH oxidase activity in phagocytes, cardiomyocytes, aortic endothelial cells, vascular smooth muscle cells, and renal mesangial cells. However, the...

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Autors principals: Hong, Nancy J., Silva, Guillermo B., Garvin, Jeffrey L.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853312/
https://ncbi.nlm.nih.gov/pubmed/20053794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00543.2009
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