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Different Members of a Simple Three-Helix Bundle Protein Family Have Very Different Folding Rate Constants and Fold by Different Mechanisms

The 15th, 16th, and 17th repeats of chicken brain α-spectrin (R15, R16, and R17, respectively) are very similar in terms of structure and stability. However, R15 folds and unfolds 3 orders of magnitude faster than R16 and R17. This is unexpected. The rate-limiting transition state for R15 folding is...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Wensley, Beth G., Gärtner, Martina, Choo, Wan Xian, Batey, Sarah, Clarke, Jane
التنسيق: Artigo
اللغة:Inglês
منشور في: Elsevier 2009
الموضوعات:
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852649/
https://ncbi.nlm.nih.gov/pubmed/19445951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.05.010
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