Bridging the gap between cytotoxic and biologic therapy with metronomic topotecan and pazopanib in ovarian cancer

To investigate the anti-tumor and anti-angiogenic effects utilizing a novel therapy regimen of metronomic topotecan and pazopanib, a multi-receptor tyrosine kinase inhibitor. In vitro (Western blot) and in vivo dose-finding experiments were performed following pazopanib therapy in ovarian cancer mod...

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Hauptverfasser: Merritt, William M., Nick, Alpa M., Carroll, Amy R., Lu, Chunhua, Matsuo, Koji, Dumble, Melissa, Jennings, Nicholas, Zhang, ShuYun, Lin, Yvonne G., Spannuth, Whitney A., Kamat, Aparna A., Stone, Rebecca L., Shahzad, Mian M.K., Coleman, Robert L., Kumar, Rakesh, Sood, Anil K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852465/
https://ncbi.nlm.nih.gov/pubmed/20371710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0967
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