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Crystallization and preliminary X-ray study of the d-­altritol oligonucleotide GTGTACAC

In altritol nucleic acids (ANAs), the natural five-membered ribose ring of RNA is replaced by the six-membered d-altritol ring. ANAs are good candidates to act as siRNAs in the RNA-interference pathway. Crystals of the fully modified altritol self-complementary octamer GTGTACAC were grown by the han...

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Main Authors: Ovaere, Margriet, Van Aerschot, Arthur, Abramov, Mikhail, Herdewijn, Piet, Van Meervelt, Luc
Format: Artigo
Jezik:Inglês
Izdano: International Union of Crystallography 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852344/
https://ncbi.nlm.nih.gov/pubmed/20383022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309110007050
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