How does hydroxyl introduction influence the double helical structure: the stabilization of an altritol nucleic acid:ribonucleic acid duplex

Altritol nucleic acids (ANAs) are a promising new tool in the development of artificial small interfering ribonucleic acids (siRNAs) for therapeutical applications. To mimic the siRNA:messenger RNA (mRNA) interactions, the crystal structure of the ANA:RNA construct a(CCGUAAUGCC-P):r(GGCAUUACGG) was...

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Hlavní autoři: Ovaere, Margriet, Sponer, Jiri, Sponer, Judit E., Herdewijn, Piet, Van Meervelt, Luc
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3424580/
https://ncbi.nlm.nih.gov/pubmed/22638588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks470
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