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Enantioselective Synthesis of (+)-Estrone Exploiting a Hydrogen Bond-Promoted Diels−Alder Reaction

[Image: see text] Starting from Dane’s diene and methylcyclopentenedione, (+)-estrone is synthesized along the Quinkert−Dane route in 24% total yield. The key step is an enantioselective Diels−Alder reaction promoted by an amidinium catalyst as efficiently as by a traditional Ti-TADDOLate Lewis acid...

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Hlavní autoři: Weimar, Marko, Dürner, Gerd, Bats, Jan W., Göbel, Michael W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2010
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852147/
https://ncbi.nlm.nih.gov/pubmed/20302330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo100053j
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