Targeted deletion of βIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes

The spectrin membrane skeleton controls the disposition of selected membrane channels, receptors, and transporters. In the brain βIII spectrin binds directly to the excitatory amino acid transporter (EAAT4), the glutamate receptor delta, and other proteins. Mutations in βIII spectrin link strongly t...

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Autores principales: Stankewich, Michael C., Gwynn, Babette, Ardito, Thomas, Ji, Lan, Kim, Jung, Robledo, Raymond F., Lux, Samuel E., Peters, Luanne L., Morrow, Jon S.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851889/
https://ncbi.nlm.nih.gov/pubmed/20231455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001522107
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