Targeted deletion of βIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes

The spectrin membrane skeleton controls the disposition of selected membrane channels, receptors, and transporters. In the brain βIII spectrin binds directly to the excitatory amino acid transporter (EAAT4), the glutamate receptor delta, and other proteins. Mutations in βIII spectrin link strongly t...

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Bibliografiske detaljer
Main Authors: Stankewich, Michael C., Gwynn, Babette, Ardito, Thomas, Ji, Lan, Kim, Jung, Robledo, Raymond F., Lux, Samuel E., Peters, Luanne L., Morrow, Jon S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851889/
https://ncbi.nlm.nih.gov/pubmed/20231455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001522107
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