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Targeted deletion of α-adducin results in absent β- and γ-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice

In the red blood cell (RBC), adducin is present primarily as tetramers of α- and β-subunits at spectrin-actin junctions, or junctional complexes. Mouse RBCs also contain small amounts of γ-adducin. Platelets contain α- and γ-adducin only. Adducin functions as a barbed-end actin capping protein to re...

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Bibliografske podrobnosti
Main Authors: Robledo, Raymond F., Ciciotte, Steven L., Gwynn, Babette, Sahr, Kenneth E., Gilligan, Diana M., Mohandas, Narla, Peters, Luanne L.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581987/
https://ncbi.nlm.nih.gov/pubmed/18723693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-05-156000
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