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Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response

The distribution and activities of morphogenic signaling proteins such as Hedgehog (Hh) and Wingless (Wg) depend on heparan sulfate proteoglycans (HSPGs). HSPGs consist of a core protein with covalently attached heparan sulfate glycosaminoglycan (GAG) chains. We report that the unmodified core prote...

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Autori principali: Williams, Elizabeth H., Pappano, William N., Saunders, Adam M., Kim, Min-Sung, Leahy, Daniel J., Beachy, Philip A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851888/
https://ncbi.nlm.nih.gov/pubmed/20231458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1001777107
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