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Role of Tyr348 in Tyr385 Radical Dynamics and Cyclooxygenase Inhibitor Interactions in Prostaglandin H Synthase-2
Both prostaglandin H synthase (PGHS) isoforms utilize a radical at Tyr385 to abstract a hydrogen atom from arachidonic acid, initializing prostaglandin synthesis. A Tyr348–Tyr385 hydrogen bond appears to be conserved in both isoforms; this hydrogen bonding has the potential to modulate the positioni...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2851202/ https://ncbi.nlm.nih.gov/pubmed/16401081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi051235w |
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