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PEROXIDE-INDUCED RADICAL FORMATION AT TYR385 AND TYR504 IN HUMAN PGHS-1
Prostaglandin H synthase isoforms 1 and -2 (PGHS-1 and -2) react with peroxide to form a radical on Tyr385 that initiates the cyclooxygenase catalysis. The tyrosyl radical EPR signals of PGHS-1 and -2 changes over time and are altered by cyclooxygenase inhibitor binding. We characterized the tyrosyl...
Gorde:
| Egile Nagusiak: | , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2009
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2697118/ https://ncbi.nlm.nih.gov/pubmed/19433337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2009.04.002 |
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