Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition

Endothelial nitric oxide synthase (eNOS) is an important regulator of vascular and cardiac function. Peroxynitrite (ONOO(−)) inactivates eNOS, but questions remain regarding the mechanisms of this process. It has been reported that inactivation is due to oxidation of the eNOS zinc-thiolate cluster,...

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Hlavní autoři: Chen, Weiguo, Druhan, Lawrence J., Chen, Chun-An, Hemann, Craig, Chen, Yeong-Renn, Berka, Vladimir, Tsai, Ah-Lim, Zweier, Jay L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851177/
https://ncbi.nlm.nih.gov/pubmed/20184376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9016632
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