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Overriding Felkin Control: A General Method for Highly Diastereoselective Chelation-Controlled Additions to α-Silyloxy Aldehydes

According to the Felkin-Anh and Cram-chelation models, nucleophilic additions to α-silyloxy aldehydes procees through a non-chelation pathway due to the steric and electronic properties of the silyl group, giving rise to Felkin addition products. Herein we describe a general method to promote chelat...

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Detalhes bibliográficos
Main Authors: Stanton, Gretchen R., Johnson, Corinne N., Walsh, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850917/
https://ncbi.nlm.nih.gov/pubmed/20218659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja910717p
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