PKCε-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line

The cholestatic bile acid taurolithocholate (TLC) inhibits biliary secretion of organic anions and hepatic uptake of taurocholate (TC). TLC has been suggested to induce retrieval of Mrp2 from the canalicular membrane via the phosphoinositide-3-kinase (PI3K)/PKB-dependent activation of novel protein...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Schonhoff, Christopher M., Yamazaki, Ai, Hohenester, Simon, Webster, Cynthia R. L., Bouscarel, Bernard, Anwer, M. Sawkat
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2009
Schlagworte:
Liver and Biliary Tract
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850086/
https://ncbi.nlm.nih.gov/pubmed/19815625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00177.2009
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