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PKCε-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line

The cholestatic bile acid taurolithocholate (TLC) inhibits biliary secretion of organic anions and hepatic uptake of taurocholate (TC). TLC has been suggested to induce retrieval of Mrp2 from the canalicular membrane via the phosphoinositide-3-kinase (PI3K)/PKB-dependent activation of novel protein...

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Main Authors: Schonhoff, Christopher M., Yamazaki, Ai, Hohenester, Simon, Webster, Cynthia R. L., Bouscarel, Bernard, Anwer, M. Sawkat
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Physiological Society 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850086/
https://ncbi.nlm.nih.gov/pubmed/19815625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00177.2009
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