PKCε-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line

The cholestatic bile acid taurolithocholate (TLC) inhibits biliary secretion of organic anions and hepatic uptake of taurocholate (TC). TLC has been suggested to induce retrieval of Mrp2 from the canalicular membrane via the phosphoinositide-3-kinase (PI3K)/PKB-dependent activation of novel protein...

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Detalhes bibliográficos
Main Authors: Schonhoff, Christopher M., Yamazaki, Ai, Hohenester, Simon, Webster, Cynthia R. L., Bouscarel, Bernard, Anwer, M. Sawkat
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Liver and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850086/
https://ncbi.nlm.nih.gov/pubmed/19815625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00177.2009
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