PKCε-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line

The cholestatic bile acid taurolithocholate (TLC) inhibits biliary secretion of organic anions and hepatic uptake of taurocholate (TC). TLC has been suggested to induce retrieval of Mrp2 from the canalicular membrane via the phosphoinositide-3-kinase (PI3K)/PKB-dependent activation of novel protein...

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Détails bibliographiques
Auteurs principaux: Schonhoff, Christopher M., Yamazaki, Ai, Hohenester, Simon, Webster, Cynthia R. L., Bouscarel, Bernard, Anwer, M. Sawkat
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2009
Sujets:
Liver and Biliary Tract
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2850086/
https://ncbi.nlm.nih.gov/pubmed/19815625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00177.2009
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