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TAUROLITHOCHOLATE-INDUCED MRP2 RETRIEVAL INVOLVES MARCKS PHOSPHORYLATION BY PROTEIN KINASE Cε IN HUH-NTCP CELLS
Taurolithocholate (TLC) acutely inhibits biliary excretion of Mrp2 substrates by inducing Mrp2 retrieval from the canalicular membrane, while cAMP increases plasma membrane MRP2. The effect of TLC may be mediated via protein kinase Cε (PKCε). Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) is...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3681903/ https://ncbi.nlm.nih.gov/pubmed/23424156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26333 |
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