Mechanism of inhibition of taurolithocholate‐induced retrieval of plasma membrane MRP2 by cyclic AMP and tauroursodeoxycholate

Taurolithocholate (TLC) produces cholestasis by inhibiting biliary solute secretion in part by retrieving MRP2 from the plasma membrane (PM). Tauroursodeoxycholate (TUDC) and cAMP reverse TLC‐induced cholestasis by inhibiting TLC‐induced retrieval of MRP2. However, cellular mechanisms for this rever...

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Bibliographic Details
Published in:Physiol Rep
Main Authors: Park, Se Won, Webster, Cynthia R. L., Anwer, Mohammed S.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727282/
https://ncbi.nlm.nih.gov/pubmed/29192063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13529
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