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Cellular Prion Protein Mediates the Toxicity of β-Amyloid Oligomers: Implications for Alzheimer Disease

Alzheimer disease (AD) is the most common cause of age-related dementia, affecting more than 25 million people worldwide. The accumulation of insoluble β-amyloid (Aβ) plaques in the brain has long been considered central to the pathogenesis of AD. However, recent evidence suggests that soluble oligo...

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Bibliographic Details
Main Authors: Nygaard, Haakon B., Strittmatter, Stephen M.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849161/
https://ncbi.nlm.nih.gov/pubmed/19901162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/archneurol.2009.223
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