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Gadolinium Ions Block Mechanosensitive Channels by Altering the Packing and Lateral Pressure of Anionic Lipids

Effects of polyvalent ions on the lateral packing of phospholipids have been known for decades, but the physiological consequences have not been systematically studied. Gd(3+) is a relatively nonspecific agent that blocks mechano-gated channels with a variable affinity. In this study, we show that t...

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Détails bibliographiques
Auteurs principaux: Ermakov, Yury A., Kamaraju, Kishore, Sengupta, Krishnendu, Sukharev, Sergei
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849073/
https://ncbi.nlm.nih.gov/pubmed/20303859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.11.044
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