The host-defense peptide piscidin P1 reorganizes lipid domains in membranes and decreases activation energies in mechanosensitive ion channels

The host-defense peptide (HDP) piscidin 1 (P1), isolated from the mast cells of striped bass, has potent activities against bacteria, viruses, fungi, and cancer cells and can also modulate the activity of membrane receptors. Given its broad pharmacological potential, here we used several approaches...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Comert, Fatih, Greenwood, Alexander, Maramba, Joseph, Acevedo, Roderico, Lucas, Laura, Kulasinghe, Thulasi, Cairns, Leah S., Wen, Yi, Fu, Riqiang, Hammer, Janet, Blazyk, Jack, Sukharev, Sergei, Cotten, Myriam L., Mihailescu, Mihaela
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2019
Sujets:
Membrane Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901303/
https://ncbi.nlm.nih.gov/pubmed/31619519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010232
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