The host-defense peptide piscidin P1 reorganizes lipid domains in membranes and decreases activation energies in mechanosensitive ion channels

The host-defense peptide (HDP) piscidin 1 (P1), isolated from the mast cells of striped bass, has potent activities against bacteria, viruses, fungi, and cancer cells and can also modulate the activity of membrane receptors. Given its broad pharmacological potential, here we used several approaches...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Comert, Fatih, Greenwood, Alexander, Maramba, Joseph, Acevedo, Roderico, Lucas, Laura, Kulasinghe, Thulasi, Cairns, Leah S., Wen, Yi, Fu, Riqiang, Hammer, Janet, Blazyk, Jack, Sukharev, Sergei, Cotten, Myriam L., Mihailescu, Mihaela
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901303/
https://ncbi.nlm.nih.gov/pubmed/31619519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010232
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