Differentiation stage-specific requirement in HIF-1α-regulated glycolytic pathway during murine B cell development in bone marrow

Hypoxia inducible factor –1α (HIF-1α) plays a central role in oxygen homeostasis and energy supply by glycolysis in many cell types. We previously reported that HIF-1α gene deficiency caused abnormal B cell development and autoimmunity. Here we show that HIF-1α-enabled glycolysis during B cell devel...

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Detalhes bibliográficos
Main Authors: Kojima, Hidefumi, Kobayashi, Ayano, Sakurai, Daisuke, Kanno, Yumiko, Hase, Hidenori, Takahashi, Riichi, Totsuka, Yoshikazu, Semenza, Gregg L., Sitkovsky, Michail V., Kobata, Tetsuji
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848717/
https://ncbi.nlm.nih.gov/pubmed/19949104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0800167
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