Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice

Immune cells are exposed to low oxygen tensions as they develop and migrate between blood and different tissues, but the mechanisms by which lymphocytes adapt to hypoxia are poorly understood. Studies reported here of hypoxia-inducible factor 1α (HIF-1α) in lymphocyte development and functions sugge...

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Bibliografiske detaljer
Main Authors: Kojima, Hidefumi, Gu, Hua, Nomura, Saeko, Caldwell, Charles C., Kobata, Tetsuji, Carmeliet, Peter, Semenza, Gregg L., Sitkovsky, Michail V.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC122337/
https://ncbi.nlm.nih.gov/pubmed/11854513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052706699
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