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Active and Repressive Chromatin Are Interspersed without Spreading in an Imprinted Gene Cluster in the Mammalian Genome
The Igf2r imprinted cluster is an epigenetic silencing model in which expression of a ncRNA silences multiple genes in cis. Here, we map a 250 kb region in mouse embryonic fibroblast cells to show that histone modifications associated with expressed and silent genes are mutually exclusive and locali...
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Autors principals: | , , , , , , , , , , |
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Format: | Artigo |
Idioma: | Inglês |
Publicat: |
2007
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Matèries: | |
Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2847180/ https://ncbi.nlm.nih.gov/pubmed/17679087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.06.024 |
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