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Long-range DNase I hypersensitivity mapping reveals the imprinted Igf2r and Air promoters share cis-regulatory elements

Epigenetic mechanisms restrict the expression of imprinted genes to one parental allele in diploid cells. At the Igf2r/Air imprinted cluster on mouse chromosome 17, paternal-specific expression of the Air noncoding RNA has been shown to silence three genes in cis: Igf2r, Slc22a2, and Slc22a3. By an...

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Main Authors: Pauler, Florian M., Stricker, Stefan H., Warczok, Katarzyna E., Barlow, Denise P.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1240080/
https://ncbi.nlm.nih.gov/pubmed/16204191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.3783805
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