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DNaseI Hypersensitivity and Ultraconservation Reveal Novel, Interdependent Long-Range Enhancers at the Complex Pax6 Cis-Regulatory Region

The PAX6 gene plays a crucial role in development of the eye, brain, olfactory system and endocrine pancreas. Consistent with its pleiotropic role the gene exhibits a complex developmental expression pattern which is subject to strict spatial, temporal and quantitative regulation. Control of express...

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מידע ביבליוגרפי
Main Authors: McBride, David J., Buckle, Adam, van Heyningen, Veronica, Kleinjan, Dirk A.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248410/
https://ncbi.nlm.nih.gov/pubmed/22220192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028616
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