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Active and Repressive Chromatin Are Interspersed without Spreading in an Imprinted Gene Cluster in the Mammalian Genome

The Igf2r imprinted cluster is an epigenetic silencing model in which expression of a ncRNA silences multiple genes in cis. Here, we map a 250 kb region in mouse embryonic fibroblast cells to show that histone modifications associated with expressed and silent genes are mutually exclusive and locali...

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Bibliografiske detaljer
Main Authors: Regha, Kakkad, Sloane, Mathew A., Huang, Ru, Pauler, Florian M., Warczok, Katarzyna E., Melikant, Balázs, Radolf, Martin, Martens, Joost H.A., Schotta, Gunnar, Jenuwein, Thomas, Barlow, Denise P.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847180/
https://ncbi.nlm.nih.gov/pubmed/17679087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.06.024
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