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APP transgenic modeling of Alzheimer’s disease: mechanisms of neurodegeneration and aberrant neurogenesis

Neurodegenerative disorders of the aging population affect over 5 million people in the US and Europe alone. The common feature is the progressive accumulation of misfolded proteins with the formation of toxic oligomers. Alzheimer’s disease (AD) is characterized by cognitive impairment, progressive...

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Bibliographic Details
Main Authors: Crews, Leslie, Rockenstein, Edward, Masliah, Eliezer
Format: Artigo
Language:Inglês
Published: Springer-Verlag 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847155/
https://ncbi.nlm.nih.gov/pubmed/20091183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00429-009-0232-6
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