Neuropeptide Y Fragments Derived from Neprilysin Processing Are Neuroprotective in a Transgenic Model of Alzheimer's Disease

The endopeptidase neprilysin (NEP) is a major amyloid-β (Aβ) degrading enzyme and has been implicated in the pathogenesis of Alzheimer's disease. Because NEP cleaves substrates other than Aβ, we investigated the potential role of NEP-mediated processing of neuropeptides in the mechanisms of neu...

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Main Authors: Rose, John B., Crews, Leslie, Rockenstein, Edward, Adame, Anthony, Mante, Michael, Hersh, Louis B., Gage, Fred H., Spencer, Brian, Potkar, Rewati, Marr, Robert A., Masliah, Eliezer
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2009
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768399/
https://ncbi.nlm.nih.gov/pubmed/19176820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4220-08.2009
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