Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice

BACKGROUND: Proteolytic degradation has emerged as a key pathway involved in controlling levels of the Alzheimer's disease (AD)-associated amyloid-β (Aβ) peptide in the brain. The endopeptidase, neprilysin, has been implicated as a major Aβ degrading enzyme in mice and humans. Previous short an...

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Detalhes bibliográficos
Main Authors: Spencer, Brian, Marr, Robert A, Rockenstein, Edward, Crews, Leslie, Adame, Anthony, Potkar, Rewati, Patrick, Christina, Gage, Fred H, Verma, Inder M, Masliah, Eliezer
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596170/
https://ncbi.nlm.nih.gov/pubmed/19014502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-9-109
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