Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice

BACKGROUND: Proteolytic degradation has emerged as a key pathway involved in controlling levels of the Alzheimer's disease (AD)-associated amyloid-β (Aβ) peptide in the brain. The endopeptidase, neprilysin, has been implicated as a major Aβ degrading enzyme in mice and humans. Previous short an...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Spencer, Brian, Marr, Robert A, Rockenstein, Edward, Crews, Leslie, Adame, Anthony, Potkar, Rewati, Patrick, Christina, Gage, Fred H, Verma, Inder M, Masliah, Eliezer
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596170/
https://ncbi.nlm.nih.gov/pubmed/19014502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-9-109
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items