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Oxidants and Ca(+2) induce PGC-1α degradation through calpain
Peroxisome proliferator activator receptor γ coactivator 1α (PGC-1α) is a transcriptional coactivator known to mediate mitochondrial biogenesis. Whereas PGC-1α transcription is regulated by a variety of signaling cascades, the mechanisms of PGC-1α degradation have received less investigation. Thus,...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2846523/ https://ncbi.nlm.nih.gov/pubmed/18718443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2008.08.003 |
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