Excess Nitric Oxide Activates TRPV1-Ca(2+)-Calpain Signaling and Promotes PEST-dependent Degradation of Liver X Receptor α

Excess nitric oxide (NO) deregulates cholesterol metabolism in macrophage foam cells, yet the underlying molecular mechanism is incompletely understood. To investigate the mechanism, we found that in macrophages, treatment with NO donors S-nitroso-N-acetyl-D,L-penicillamine (SNAP) or diethylenetriam...

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Podrobná bibliografie
Vydáno v:Int J Biol Sci
Hlavní autoři: Zhao, Jin-Feng, Shyue, Song-Kun, Lee, Tzong-Shyuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679395/
https://ncbi.nlm.nih.gov/pubmed/26722214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.13549
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