Excess Nitric Oxide Activates TRPV1-Ca(2+)-Calpain Signaling and Promotes PEST-dependent Degradation of Liver X Receptor α

Excess nitric oxide (NO) deregulates cholesterol metabolism in macrophage foam cells, yet the underlying molecular mechanism is incompletely understood. To investigate the mechanism, we found that in macrophages, treatment with NO donors S-nitroso-N-acetyl-D,L-penicillamine (SNAP) or diethylenetriam...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Int J Biol Sci
Egile Nagusiak: Zhao, Jin-Feng, Shyue, Song-Kun, Lee, Tzong-Shyuan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Ivyspring International Publisher 2016
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679395/
https://ncbi.nlm.nih.gov/pubmed/26722214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.13549
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