Intermittent hypoxia degrades HIF-2α via calpains resulting in oxidative stress: Implications for recurrent apnea-induced morbidities

Intermittent hypoxia (IH) occurs in many pathological conditions including recurrent apneas. Hypoxia-inducible factors (HIFs) 1 and 2 mediate transcriptional responses to low O(2). A previous study showed that HIF-1 mediates some of the IH-evoked physiological responses. Because HIF-2α is an ortholo...

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Main Authors: Nanduri, Jayasri, Wang, Ning, Yuan, Guoxiang, Khan, Shakil A., Souvannakitti, Dangjai, Peng, Ying-Jie, Kumar, Ganesh K., Garcia, Joseph A., Prabhakar, Nanduri R.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2009
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626608/
https://ncbi.nlm.nih.gov/pubmed/19147445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811018106
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