Human Carboxylesterase 1 Stereoselectively Binds the Nerve Agent Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent Sarin

Organophosphorus (OP) nerve agents are potent toxins that inhibit cholinesterases and produce a rapid and lethal cholinergic crisis. Development of protein-based therapeutics is being pursued with the goal of preventing nerve agent toxicity and protecting against the long-term side effects of these...

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Main Authors: Hemmert, Andrew C., Otto, Tamara C., Wierdl, Monika, Edwards, Carol C., Fleming, Christopher D., MacDonald, Mary, Cashman, John R., Potter, Philip M., Cerasoli, Douglas M., Redinbo, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845941/
https://ncbi.nlm.nih.gov/pubmed/20051531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.062356
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