Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme

Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poisoning. Here we impart nerve agent hydrolysis activit...

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Bibliografiske detaljer
Main Authors: Hemmert, Andrew C., Otto, Tamara C., Chica, Roberto A., Wierdl, Monika, Edwards, Jonathan S., Lewis, Steven L., Edwards, Carol C., Tsurkan, Lyudmila, Cadieux, C. Linn, Kasten, Shane A., Cashman, John R., Mayo, Stephen L., Potter, Philip M., Cerasoli, Douglas M., Redinbo, Matthew R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060870/
https://ncbi.nlm.nih.gov/pubmed/21445272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017441
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