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Tumour‐selective targeting of drug metabolizing enzymes to treat metastatic cancer

Carboxylesterases (CEs) are ubiquitous enzymes responsible for the detoxification of ester‐containing xenobiotics. This hydrolysis reaction results in the formation of the corresponding carboxylic acid and alcohol. Due to their highly plastic active site, CEs can hydrolyze structurally very distinct...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Wierdl, Monika, Tsurkan, Lyudmila, Hatfield, M Jason, Potter, Philip M
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5055134/
https://ncbi.nlm.nih.gov/pubmed/27423046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13553
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