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Apamin as a novel template for structure-based rational design of potent peptide activators of p53
[Image: see text] The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the tumor suppressor protein p53, and are important molecular targets for anticancer therapy. Grafting four residues critical for MDM2/MDMX binding to the C-terminal α-helix of apamin converts the bee-...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2845718/ https://ncbi.nlm.nih.gov/pubmed/19827079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.200904550 |
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