Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX

The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the tumor suppressor protein p53—a cellular process initiated by MDM2 and/or MDMX binding to the N-terminal transactivation domain of p53. MDM2 and MDMX in many tumors confer p53 inactivation and tumor survival, and are...

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Detalhes bibliográficos
Main Authors: Pazgier, Marzena, Liu, Min, Zou, Guozhang, Yuan, Weirong, Li, Changqing, Li, Chong, Li, Jing, Monbo, Juahdi, Zella, Davide, Tarasov, Sergey G., Lu, Wuyuan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660734/
https://ncbi.nlm.nih.gov/pubmed/19255450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900947106
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