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An Ultrahigh Affinity D-Peptide Antagonist Of MDM2

The oncoprotein MDM2 negatively regulates the activity and stability of the p53 tumor suppressor, and is an important molecular target for anticancer therapy. Aided by mirror image phage display and native chemical ligation, we have previously discovered several proteolysis-resistant duodecimal D-pe...

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Detalhes bibliográficos
Main Authors: Zhan, Changyou, Zhao, Le, Wei, Xiaoli, Wu, Xueji, Chen, Xishan, Yuan, Weirong, Lu, Wei-Yue, Pazgier, Marzena, Lu, Wuyuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426300/
https://ncbi.nlm.nih.gov/pubmed/22694121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3005465
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