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Systematic Mutational Analysis of Peptide Inhibition of the p53-MDM2/MDMX Interactions
Inhibition of the interaction between the tumor suppressor protein p53 and its negative regulators MDM2 and MDMX is of great interest in cancer biology and drug design. We previously reported a potent duodecimal peptide inhibitor, termed PMI (TSFAEYWNLLSP), of the p53-MDM2 and -MDMX interactions. PM...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856455/ https://ncbi.nlm.nih.gov/pubmed/20226197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.03.005 |
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