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Rational Design of p53, an Intrinsically Unstructured Protein, for the Fabrication of Novel Molecular Sensors
The dominant paradigm of protein engineering is structure-based site-directed mutagenesis. This rational approach is generally more effective for the engineering of local properties, such as substrate specificity, than global ones such as allostery. Previous workers have modified normally unregulate...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2005
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2045634/ https://ncbi.nlm.nih.gov/pubmed/16118206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M508149200 |
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