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Antibody-induced oligomerization and activation of an engineered reporter enzyme
Our objective is to produce a protein biosensor (or molecular switch) that is specifically activated in solution by a monoclonal antibody. Many effector-dependent enzymes have evolved in nature, but the introduction of a novel regulatory mechanism into a normally unregulated enzyme poses a difficult...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1995550/ https://ncbi.nlm.nih.gov/pubmed/17467736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.03.076 |
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